The aglycone , steviol , exhibited greater acute toxicity than stevioside in hamsters but not in rats . steviol was clearly genotoxic after metabolic activation , inducing forward mutations in bacteria and gene mutations and chromosomal aberrations in lung fibroblasts of chinese hamsters
3.
The bell - shaped time course of the information entropy indicates that a forward mutation of " - resistant " hosts takes place , since no loss of cellular viability occurs for the second growth phase of reinduced ( i . e . recovered ) cells
4.
The aglycone , steviol , exhibited greater acute toxicity than stevioside in hamsters but not in rats . steviol was clearly genotoxic after metabolic activation , inducing forward mutations in bacteria and gene mutations and chromosomal aberrations in lung fibroblasts of chinese hamsters
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